Wednesday, January 31, 2007

A woman, one of three people who recently died of flu like symptoms, in Lagos, Nigeria, has tested positive for the H5N1 strain of Avian influenza.

It is the first bird flu in Nigeria since the strain arrived in Nigeria a year ago. H5N1 was confirmed in blood samples tested in Rome and London from the three recent deaths.

The Food and Agriculture Organization of the United Nations stated that while the threat from avian flu has decreased from last year, there still remains flare-ups around the world, urging countries to “remain vigilant and fully cooperate with international organizations”.

Bird flu is spread by wild birds for whom the virus is a stomach disease and, generally, not fatal.

Although the disease has killed 164 people, it has only been out of 269 cases, this gives the disease around a 60% fatality rate compared to the 1918 ‘Spanish flu’ pandemic which had a mortality rate of around 5%.

The outer coat of the virus particle is characterised by two types of glyco-proteins, neurominidase and haemagglutinin, both of which interact with sialic acid.

Haemagglutinin has sixteen forms, H1 to H16, and binds to sialic acid on the target cell, facilitating the entry of the virus.

Neurominidase is found in nine forms, N1 to N9, this protein allows the progeny viri to escape the infected cell by cleaving sialic acid.

The two main drugs against bird flu currently on the market, Tamiflu^® and Relenza^®, both target the sialic acid binding pocket of neurominidase. Neither of these drugs will cure the disease, but will stop its spread through the body. As such they have to be administered within 48 hours of symptoms appearing. In all 9 sub types of neurominidase, the structure of the target area for the drugs is the same. There is also a flu vaccine but the current flu vaccine does not protect against H5N1.

Human to human transmission is very rare, at the moment bird flu can only be caught from prolonged exposure to infected birds, specifically their droppings from which the bird flu virus has been crystallized and parts of the structure solved.

Unlike diseases such as smallpox and measles, for which their are effectively protecting vaccines, the flu virus constantly mutates. Each year the virus is slightly different from the last, this is the genetic drift of the virus – small point mutations on the surface, causing an evasion of our immune system. Many of the problems arise when there is a major shift of the surface proteins, for instance when a different subtype appears, such as H5.

There are three strains of human influenza circulating around the globe; H1N1 first isolated in 1933, H2N2 first isolated in 1957 and H3N2 first isolated in 1968. Other than humans; pigs, seals and horses have various strains of influenza, however only wild birds have all the known subtypes of haemagglutinin and neurominidase. Of the 144 combinations of N(1-9) and H(1-16) we have had three.

Thursday, July 28, 2005

The Provisional Irish Republican Army, in a statement released earlier today (in one form as a DVD, with the statement being read by Séanna Breathnach), has declared that it intends to end its campaign of violence and decommission its weapons.

The move comes after international pressure to decommission weapons and cease all violent activity, particularly after allegations regarding the murder of Robert McCartney in Short Strand, Belfast, and a burglary of the Northern Bank in December of last year.

Members have been ordered to dump all arms and cease all paramilitary activity as of 16.00 BST (15.00 UTC) today, and the organisation’s leadership states that it will pursue its aims through exclusively peaceful means. The statement reaffirms the IRA’s view that its “armed struggle was entirely legitimate” as a means of pursuing the organisation’s goal of a united Ireland, but states that many suffered during this conflict and that society is now compelled to build a lasting peace.

In its statement the IRA also appealed to the British government and Northern Irish Protestants to renew negotiations with them.

Reaction to the statement has been mixed.

• “I think it has all the clarity that people have looked for this past 12 months. Of course there are lots of other issues in the peace process, which we have to continue to build on and build confidence on” — Bertie Ahern, Taoiseach (Irish Prime Minister)
• “This may be the day when finally, after all the false dawns and dashed hopes, peace replaced war, politics replaces terror on the island of Ireland. […] It is what we have striven for and worked for throughout the eight years since the Good Friday Agreement.” — Tony Blair, Prime Minister of the United Kingdom
• “For the first time we have heard directly from the IRA not Sinn Fein that henceforward they are going to adopt peaceful means in seeking their political objectives” — Peter Mandelson, European Union Commissioner, former Northern Ireland Secretary
• “11 years after the first IRA ceasefire these are the words that we needed and wanted to hear.” — Alex Attwood, SDLP
• “I know there have been some who have been sceptical about whether republicans, the IRA in particular, were really interested in this process. I think today’s statement shows that they are. The IRA doesn’t have to do this. It is only doing this to try and give some assurance to those who are nervous or who are genuinely concerned. The IRA is not just stretching itself. It is actually overstretching itself to try to bring about the restoration of the peace process.” — Gerry Adams, Sinn Fein President

Saturday, April 17, 2010

Journalist, counselor, painter, and US 2012 Presidential candidate Joe Schriner of Cleveland, Ohio took some time to discuss his campaign with Wikinews in an interview.

Schriner previously ran for president in 2000, 2004, and 2008, but failed to gain much traction in the races. He announced his candidacy for the 2012 race immediately following the 2008 election. Schriner refers to himself as the “Average Joe” candidate, and advocates a pro-life and pro-environmentalist platform. He has been the subject of numerous newspaper articles, and has published public policy papers exploring solutions to American issues.

Wikinews reporter William Saturn? talks with Schriner and discusses his campaign.

Friday, March 9, 2007

IBM and Cisco have announced the development of a new platform, based on Eclipse and OSGi (Open Services Gateway initiative), which should unite all communication and collaboration software developers under a single platform.

Before the UC2 (Unified Communication and Collaboration) the unified communication has suffered because of a lack of a platform to be used by all software developers, rather than a series of them and, moreover, provided by different vendors. According to Adam Gartenberg from IBM Lotus Software Group this was the main cause for this partial stagnation.

However, the UC2 is meant to ease the work of software developers. Gartenberg stated that this platform is very flexible and will certainly draw much attention form programmers. They will be able to create different plug-ins and small applications to remotely control other, major application.

The companies have also unveiled a series of their other joint projects. These project will be based on a set of application programming interface from Lotus (SameTime) and Cisco.

The add-ons planned are integration of a series of additional functions and features into the SameTime software from Lotus. Thus, in a few months, the SameTime users will benefit from such functions as click-to-call and voicemail. This will enable easier instant messaging inside the Cisco’s Unified IP phones’ system.

The fact that the platform will be based on Eclipse will make the numerous developers create many communications services, mainly for remote users to benefit from a series of new functions of ERP and CRM applications.

Nortel Networks – a partner of Microsoft since last year and Cisco’s rival in the area – didn’t have much success in the communication services field.

As for Microsoft, the experts are waiting for the reaction of the Bill Gates’ company on the ideas and offers made by IBM and Cisco for enterprise communications and collaboration solutions.

Saturday, June 18, 2005

MasterCard International announced Friday that multiple instances of fraud have been tracked back to CardSystems Solutions, Inc., a company that processes credit card transactions and other payments. Customer names, banks, and account numbers of up to 40 million cardholders have been exposed, of which about 13.9 million are MasterCard-branded cards, the company said. Visa and American Express cards were also affected.

“The breach appears to be the largest yet involving financial data,” said David Sobel, of the Electronic Privacy Information Center.

CardSystems issued a statement late on Friday that said it learned of the potential breach 26 days ago, but that the FBI told the company not to advise the cardholders nor the public at large. CardSystems also said their statement had been vetted by the FBI.

A spokesperson for the FBI said that the agency had asked CardSystems not to disclose information that could compromise the investigation, but that it had not asked CardSystems to fail to disclose the breach at all.

Michael A. Brady, C.F.O. of CardSystems, told the Associated Press that “we’re absolutely blindsided by a press release by the association,” when speaking of MasterCard’s release. A MasterCard spokesperson said that the company was obligated to inform its customers of the breach.

MasterCard spokesperson Sharon Gamsin said that CardSystems was hit by a virus-like computer script that stole customer data for the purpose of fraud. She said MasterCard does not know how the script got into the CardSystem network.

Sobel said this theft “indicates that this is a shadowy industry where the consumer never really knows who is going to be handling and using their personal information. Presumably, the affected consumers thought they were dealing with MasterCard.” Having a third-party process credit card transactions is common practice in the industry.

Wednesday, April 18, 2007

The Supreme Court of the United States on Wednesday April 18 has upheld the federal Partial-Birth Abortion Ban Act of 2003. The 5-4 vote reflected the change in vote count resulting from the retirement of Justice O’Connor and the confirmation of Chief Justice Roberts and Justice Alito.

The Intact dilation and extraction procedure, also known as partial birth abortion, involves removing an intact late-term fetus from the womb via the cervix. While it is a relatively rare operation – 0.17% of all abortions in the US in 2000, it has become a focal point in the abortion debate.

The Partial-Birth Abortion Ban Act bans the procedure in cases where the fetus is terminated during the operation, unless it is performed to to save the life of the mother.

Justice Kennedy wrote in the opinion of the court: “respondents have not demonstrated that the Act would be unconstitutional in a large fraction of relevant cases.” Further, he said, “Respondents have not demonstrated that the Act, as a facial matter, is void for vagueness, or that it imposes an undue burden on a woman’s right to abortion based on its overbreadth or lack of a health exception. For these reasons the judgments of the Courts of Appeals for the Eighth and Ninth Circuits are reversed.”

In a concurring opinion, Justice Thomas stated that he joins “the Court’s opinion because it accurately applies current jurisprudence, including Planned Parenthood of Southeastern Pa. v. Casey, 505 U. S. 833 (1992).”

In dissent Judge Ginsburg wrote: “Today’s decision is alarming. It refuses to take Casey and Stenberg seriously. It tolerates, indeed applauds, federal intervention to ban nationwide a procedure found necessary and proper in certain cases by the American College of Obstetricians and Gynecologists.”

Justice Kennedy’s words also recall the complicated issues of standing related to such cases. An issue in Roe v. Wade was the impossibility of any individual having standing in a court proceeding regarding abortion rights, since court proceedings take more than the 9 months of pregnancy, retiring any individual plaintiff’s standing before an appeals process can take place. The criterion of “a large fraction of relevant cases” may effectively deny standing to any plaintiffs who wish to litigate particular restrictions in some relevant future cases.