Sunday, April 1, 2007

In Estonia, a mouse made its nest in a cash machine and spent the weekend eating tens of thousands of kroons in bank notes. The critter was discovered after a customer making a withdrawal got half-eaten bills from the machine.

Experts are now investigating how the rodent was able to get into the ATM.

Friday, January 26, 2007

Ângelo A. Chora et. al. are reporting in the Journal of Clinical Investigation this week that carbon monoxide (CO) and the heme oxygenase-1 protein protect against the symptoms of multiple sclerosis (MS) in the related mouse model of experimental autoimmune encephalomyelitis (EAE).

Multiple sclerosis is a chronic, inflammatory disease that affects the central nervous system (CNS). Although many patients are largely unaffected by their disease, MS can cause impaired mobility and disability in more severe cases.

The research group from the Gulbenkian Institute in Portugal used the EAE mouse model of MS to study the effects of the Heme oxygenase-1 (HO-1) protein encoded by the HMOX1 gene.

HO-1 knockout mice, lacking both copies of the gene (not producing the protein), showed a more severe progression of the disease compared to wild-type mice, having normal levels of the protein. The symptoms of the disease were reversed when the HO-1 protein expression was induced using cobalt protoporphyrin IX.

During MS attacks the body’s own immune system destroys the myelin sheath surrounding nerve cells in the brain and spinal cord. Pathogenic T helper cells are triggered by Antigen-presenting cell (APCs) within the brain stem. The disease can cycle between attacks (relapses) followed by remission, suggesting that there is an underlying regulatory system. The HO-1 protein had been identified previously as a possible candidate for a protective gene.

HO-1 degrades excess heme within the body acting as the rate controlling step when under inflammatory conditions. The HO-1 heme degradation pathway produces as products equal amounts of free heme, carbon monoxide and biliverdin.

Carbon monoxide was also shown to limit the effects of the disease. Mice were exposed to a high concentration of CO for 20 days within a chamber. Mice exposed to CO had limp tails, but were more mobile than the mice in the control experiment which displayed hind limb paralysis.

It is still unknown exactly how carbon monoxide slows down the symptoms of EAE, possibly through the mopping up of free radicals, or through promoting the binding of iron to heme (decreasing radical production).

The experiments found that HO-1 did not affect the development or function of regulatory T cells. For a beneficial effect HO-1 needed to be expressed in dendritic cells, causing inhibition of MHC-II proteins, involved in presenting antigens, and inflammatory cytokines (IFN-?).

These experiments open up new possibilities for MS therapies, involving the expression of HO-1 in suppressing the development of MS.

The article went online on the 25th January 2007 and will be printed in the Journal of Clinical Investigation in February.

Sunday, October 18, 2020

The spread of coronavirus in late 2019 and then in 2020 led to a global pandemic, effecting various daily activities. Originated in Wuhan, China, the virus spread globally, and by March, drastic measures were taken by the Indian government. Some branches of the South Western Railway of India had started taking precautions by distributing masks to ticket collectors and guards from as early as March 8. Some colleges were suspended by March 13, their exams postponed as the government introduced lockdown and enforced social distancing.

Announced in the evening, Indian Prime Minister asked the countrymen to get the essential products and avoid going out as much as possible. Long queues outside the grocery shops, people in masks, some in N-95 masks, and hand sanitisers at the gates of megamarts were a common sight. There were reduced items in the shops, and some stores had a limit of number of customers allowed in the store at any given time. Food delivery services, and taxi services were on hiatus — workers who dependent on the profession for their daily income, while people including software engineers were working from home. Physical classes in schools and colleges were replaced by online lectures to prevent social gatherings.

While many relied on technology for continuing their work and earn their livelihood, Wikinews reached out to sex workers in Mysore in June who unlike others can’t maintain social distancing for their work. Two sex workers, Akram Pasha, and Jaya (a pseudonym), who were a part of sex worker’s group called “Ashodaya Samithi” discussed how their lives had been effected by the coronavirus, the lockdown and the restrictions they had faced.

Monday, October 25, 2010

Five police officers were injured as they attempted to quell a demonstration over plans to build a large garbage tip on the edge of an Italian town, officials confirmed on Saturday. Two police officers and three carabinieri suffered minor injures during the protest, which lasted several hours. Residents of Terzigno, a municipality in the Province of Naples, hurled stones and fireworks at the police, who responded by attempting to disperse the demonstrators using teargas and baton charges. Protesters are campaigning against the opening of a new waste dump near the town, and the incident on Saturday is the latest in a series of demonstrations in which campaigners are preventing access to the existing garbage tip.

The blockade means waste disposal workers are unable to collect refuse, and it has been reported that 2,000 tones of rubbish has already piled up on the streets of Naples. Protesters set the garbage alight on Friday evening, Rosa Russo Iervolino, the mayor of Naples confirmed. Some protesters burned Italian flags and set cars on fire. “The bad smell bothers us, but it is the lesser evil,” one protester, a grammar school teacher, said. “The most important thing is that we are dying here, there is leukaemia, lymphoma, myeloma, there are the most terrible diseases around.” Two parents added that their children were suffering from respiratory problems and paediatricians had advised them to move away from the area. “They have ruined our lives, the lives of our children who are growing up in a world of rubbish, they are destroying our lives day by day,” said one.

In 2007, Prime Minister of Italy Silvio Berlusconi pledged to create a solution to Italy’s ever-growing problem with litter. However, a European commisioner has warned the Italian government that they may face legal action from the European Union (EU), who may be able to fine them for failing to improve waste management in Naples. “I am worried by what has been happening in Campania in recent days,” said Janez Poto?nik, the European Commissioner for the Environment. He added that the EU were considering sending a team to the area to assess whether laws protecting human health and the enviroment were being breached. “Today’s situation leads us to believe that measures taken by Italian authorities since 2007 are insufficient,” he said. “What has been happening in the last days shows that the Italian authorities have not yet done what is needed.” Mr. Poto?nik added that he felt that the region still had no waste management and that the only incinerator “is not functioning properly and at full capacity.”

Friday, June 19, 2020

The following is the first edition of a monthly series chronicling the 2020 United States presidential election. It features original material compiled throughout the previous month after an overview of the month’s biggest stories.

This month’s spotlight on the campaign trail includes interviews with the vice presidential nominees of the Constitution and Libertarian parties as well as the chosen running mate of the leading Green Party presidential candidate.

Tuesday, July 6, 2010

The Northeastern region of the United States has been blanketed by a severe heat wave since Sunday, with temperatures predicted to reach over a hundred degrees Fahrenheit Tuesday.

The US National Weather Service (NWS) issued warnings of severe heat for most of the East Coast as well as some inland states, which are predicted to have temperatures as high as 102 degrees Fahrenheit. Factoring in humidity levels in a measurement called a heat index, temperatures will be even higher; New York City’s heat index could reach 107 degrees.

An NWS meteorologist, Brian Korty in Maryland, said that hot air is “sitting over the top of us, and it’s not really going to budge much for the next day or two,” after which cooler air coming from the Atlantic Ocean is expected to arrive.

Officials warned of health risks from the high heat; an NWS statement said to “check on your elderly relatives and neighbors. Coaches, trainers, camp counselors should remain alert for signs of heat exhaustion and heat stroke. It will be so hot this afternoon that the weather could affect anyone no matter their age or overall health. Please consider postponing strenuous activities or work outs.”

Electric utility companies are concerned about the effect of the heat on infrastructure; New York’s Consolidated Edison said that several hundred people were without power Tuesday morning. In Philadelphia, as many as 8,000 people were without power Monday; the number has decreased to around 400, but is expected to rise again later on Tuesday.

Sunday, March 25, 2018

Visual art, fabric art, photography, performance, dance, virtual reality, and music were all the subject of sessions at Furnal Equinox 2018, a conference held from March 16 to 18 at Toronto’s Westin Harbour Castle. Canada’s largest furry convention by attendance, the annual event offers dozens of subculture-specific programs.

The convention’s communications and public relations coordinator for the event, Ronnie, describes furries as “people that enjoy arts and culture centred around animals and animal-themed topics, essentially. Furnal Equinox in particular, we like to celebrate in a very visual and very […] artistic nature, where we have lots of arts and performances and crafts that go on, and people celebrate with lots of socialisation involved.”

Of the attendees, Ronnie told Wikinews “they come from all walks of life. They are people of all ages, sizes, all sorts of backgrounds, and they come together under one mutual interest, which is their love for animal culture.”

“Programming at Furnal Equinox involves[…] a lot of informational panels, so you can find out about topics from art and how to draw, or how to visually incorporate different elements into your artworks. You can also find panels that teach you how to write better, be a better fiction author for example,” explained the event representative.

At one panel Wikinews attended, members of its all-volunteer organising committee spoke of the year-long process of planning the event, and their reasons for committing such a significant amount of their time. Said one panelist, “if you’re happy, we’re happy.”

• Image: Nicholas Moreau.

• Image: Nicholas Moreau.

• Image: Nicholas Moreau.

The largest hub of activity at the convention was a dealer’s room; nicknamed the “Dealer’s Den”, giving it an anthropomorphic twist. Vendors were selling original visual art, wearables like faux fur tails or ears, or things like jewellery or soap with motifs that would interest attendees.

The back area of the room was dedicated to a charity auction, with proceeds benefiting Happily Ever Esther Farm Sanctuary. According to the convention website, the charity is “dedicated to rescuing abused, neglected, and abandoned farmed animals. Their goal is to provide a safe, life-long home for all of their residents, and to educate the public about the true nature of farmed animals through tours, volunteer programs, and community outreach.”

Split into groups, some attendees played “Fursuit Games” in front of an audience, like trying to toss a ball into a garbage can. The activity made harder, of course, by the limited dexterity and vision the most of the costumes entail.

• Image: Nicholas Moreau.

• Image: Nicholas Moreau.

• Berrie Image: Nicholas Moreau.

• Image: Nicholas Moreau.

• Attendees try to catch their own prizes, like t-shirts, after the Games. Image: Nicholas Moreau.